HORDB

ID: hor005585
Uniprot ID: Q9IA08
Protein name: GnRH-associated peptide 2
Gene name: gnrh2
Organism: Dicentrarchus labrax (European seabass) (Morone labrax)
Family: GnRH family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Dicentrarchus (genus), Moronidae (family), Eupercaria incertae sedis, Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: ELDSFGTSEISEEIKLCEAGECSYLRPQRRSVLRNIILDALARELQKRK
Length: 49(37-85)
Propeptide: MCVSRLVLLFGLLLCVGAQLSNAQHWSHGWYPGGKRELDSFGTSEISEEIKLCEAGECSYLRPQRRSVLRNIILDALARELQKRK
Signal peptide: MCVSRLVLLFGLLLCVGAQLSNA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005585_AF2.pdb

hor005585_ESM.pdb

Mass:	652183	Formula:	C243H409N73O78S2
Absent amino acids:	HMW	Common amino acids:	EL
pI:	6.54	Basic residues:	9
Polar residues:	12	Hydrophobic residues:	16
Hydrophobicity:	-55.31	Boman Index:	-13770
Half-Life:	1 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	99.59
Instability Index:	10343.47	Extinction Coefficient cystines:	1615
Absorbance 280nm:	33.65

PubMed ID: 11086295
Title: Differential expression of three different prepro-GnRH (gonadotrophin-releasing hormone) messengers in the brain of the European sea bass (Dicentrarchus labrax).