HORDB

ID: hor005559
Uniprot ID: Q8MJ80
Protein name: Hepcidin
Gene name: HAMP
Organism: Sus scrofa (Pig)
Family: Hepcidin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0006879 intracellular iron ion homeostasis; GO:0007165 signal transduction; GO:0010039 response to iron ion; GO:0034760 negative regulation of iron ion transmembrane transport; GO:0042742 defense response to bacterium; GO:0060586 multicellular organismal-level iron ion homeostasis; GO:1904479 negative regulation of intestinal absorption
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: DTHFPICIFCCGCCRKAICGMCCKT
Length: 25
Propeptide: MALSVQIRAACLLLLLLVSLTAGSVLPSQTRQLTDLRTQDTAGATAGLTPVAQRLRRDTHFPICIFCCGCCRKAICGMCCKT
Signal peptide: MALSVQIRAACLLLLLLVSLTAG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005559_AF2.pdb

hor005559_ESM.pdb

Mass:	318573	Formula:	C113H182N32O30S9
Absent amino acids:	ELNQSVWY	Common amino acids:	C
pI:	7.97	Basic residues:	4
Polar residues:	12	Hydrophobic residues:	6
Hydrophobicity:	80	Boman Index:	-754
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	50.8
Instability Index:	714.4	Extinction Coefficient cystines:	500
Absorbance 280nm:	20.83