General Information

  • ID:  hor005520
  • Uniprot ID:  P33528
  • Protein name:  Glucagon-like peptide
  • Gene name:  gcg
  • Organism:  Amia calva (Bowfin)
  • Family:  Glucagon family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Amia (genus), Amiidae (family), Amiiformes (order), Holostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0050896 response to stimulus
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YADAPYISDVYSYLQDQVAKKWLKSGQDRRE
  • Length:  31(45-75)
  • Propeptide:  HSQGTFTNDYSKYMDTRRAQDFVQWLMSTXXXXXXXXXXXXXXXYADAPYISDVYSYLQDQVAKKWLKSGQDRRE
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005520_AF2.pdbhor005520_ESM.pdb

Physical Information

Mass: 422937 Formula: C166H250N44O52
Absent amino acids: CFHMNT Common amino acids: DY
pI: 6.62 Basic residues: 5
Polar residues: 8 Hydrophobic residues: 9
Hydrophobicity: -107.42 Boman Index: -8402
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 66.13
Instability Index: 5615.48 Extinction Coefficient cystines: 11460
Absorbance 280nm: 382

Literature

  • PubMed ID:  8240302
  • Title:  Structure and biological activity of glucagon and glucagon-like peptide from a primitive bony fish, the bowfin (Amia calva).