HORDB

ID: hor005489
Uniprot ID: P01300
Protein name: Pancreatic icosapeptide
Gene name: PPY
Organism: Sus scrofa (Pig)
Family: NPY family
Source: Animal
Expression: Induced in hypoglycemia, and, in vitro, by carbocal, in fetal pancreatic cells.
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031841 neuropeptide Y receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0007631 feeding behavior
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: DEEDLLDLKCSSLHAAAPR
Length: 19(40-58)
Propeptide: APLEPVYPGDDATPEQMAQYAAELRRYINMLTRPRYGKRDEEDLLDLKCSSLHAAAPRELSPMGA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Induced in hypoglycemia
Mechanism: May be used as a marker of the viability of xenotransplanted fetal panreatic tissue in the immediate post-transplant period.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005489_AF2.pdb

hor005489_ESM.pdb

Mass:	240457	Formula:	C87H143N25O32S
Absent amino acids:	FGIMNQTVWY	Common amino acids:	L
pI:	4.23	Basic residues:	3
Polar residues:	3	Hydrophobic residues:	7
Hydrophobicity:	-48.42	Boman Index:	-4532
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	97.89
Instability Index:	4860.53	Extinction Coefficient cystines:	0
Absorbance 280nm:	0