General Information

  • ID:  hor005485
  • Uniprot ID:  P11952
  • Protein name:  Relaxin A chain
  • Gene name:  NA
  • Organism:  Leucoraja erinacea (Little skate) (Raja erinacea)
  • Family:  insulin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Leucoraja (genus), Rajidae (family), Rajiformes (order), Batoidea (superorder), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  EEKMGFAKKCCAIGCSTEDFRMVC
  • Length:  24(41-64)
  • Propeptide:  RPNWEERSRLCGRDLIRAFIYLCGGTRWTRLPNFGNYPIMEEKMGFAKKCCAIGCSTEDFRMVC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45945
  • Structure ID:  AF-P11952-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005485_AF2.pdbhor005485_ESM.pdb

Physical Information

Mass: 309763 Formula: C111H180N30O35S6
Absent amino acids: HLNPQWY Common amino acids: C
pI: 6.26 Basic residues: 4
Polar residues: 8 Hydrophobic residues: 6
Hydrophobicity: -3.33 Boman Index: -3645
Half-Life: 1 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 36.67
Instability Index: 4965.83 Extinction Coefficient cystines: 250
Absorbance 280nm: 10.87

Literature

  • PubMed ID:  3827922
  • Title:  Relaxin from an oviparous species, the skate (Raja erinacea).