HORDB

ID: hor005477
Uniprot ID: P09687
Protein name: Glucagon-like peptide
Gene name: gcg
Organism: Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
Family: Glucagon family
Source: Animal
Expression: Produced in the A cells of the islets of Langerhans in response to a drop in blood sugar concentration.
Disease: NA
Comments: NA
Taxonomy: Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005477_AF2.pdb

hor005477_ESM.pdb

Mass:	383021	Formula:	C149H221N37O50
Absent amino acids:	CIMNPQW	Common amino acids:	S
pI:	5.61	Basic residues:	5
Polar residues:	11	Hydrophobic residues:	8
Hydrophobicity:	-73.79	Boman Index:	-7204
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	53.79
Instability Index:	984.83	Extinction Coefficient cystines:	4470
Absorbance 280nm:	159.64