HORDB

ID: hor005468
Uniprot ID: P68992
Protein name: Insulin A chain
Gene name: ins
Organism: Hydrolagus colliei (Spotted ratfish) (Chimaera colliei)
Family: insulin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Hydrolagus (genus), Chimaeridae (family), Chimaeriformes (order), Holocephali (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005468_AF2.pdb

hor005468_ESM.pdb

Mass:	262848	Formula:	C91H143N27O33S4
Absent amino acids:	DFKMPRW	Common amino acids:	C
pI:	4.25	Basic residues:	1
Polar residues:	12	Hydrophobic residues:	5
Hydrophobicity:	1.43	Boman Index:	-2224
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	74.29
Instability Index:	2573.33	Extinction Coefficient cystines:	1740
Absorbance 280nm:	87

PubMed ID: 3780981
Title: The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing.
PubMed ID: 2646172
Title: Multiple molecular forms of insulin and glucagon-like peptide from the Pacific ratfish (Hydrolagus colliei).