HORDB

ID: hor005459
Uniprot ID: Q9XZE6
Protein name: Eclosion hormone
Gene name: NA
Organism: Romalea microptera (Eastern lubber grasshopper) (Romalea guttata)
Family: insect eclosion hormone family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Romalea (genus), Romaleinae (subfamily), Romaleidae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0008255 ecdysis-triggering hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0018990 ecdysis, chitin-based cuticle
GO CC: GO:0005576 extracellular region

Function: Neuropeptide that triggers the performance of ecdysis behaviors at the end of a molt. It triggers adult behavior patterns: larval, pupal and adult ecdysis, and plasticization during the molt
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q9XZE6-F1.pdb

hor005459_AF2.pdb

hor005459_ESM.pdb

Mass:	682932	Formula:	C247H413N71O75S9
Absent amino acids:	HNQW	Common amino acids:	S
pI:	9.23	Basic residues:	10
Polar residues:	23	Hydrophobic residues:	13
Hydrophobicity:	-17.64	Boman Index:	-8427
Half-Life:	1.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	49.82
Instability Index:	5776	Extinction Coefficient cystines:	1865
Absorbance 280nm:	34.54