HORDB

ID: hor005389
Uniprot ID: C0HJI5
Protein name: Insulin-1 B chain
Gene name: NA
Organism: Thunnus orientalis (North Pacific bluefin tuna) (Thunnus thynnus orientalis)
Family: insulin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Thunnus (genus), Thunnini (tribe), Scombrinae (subfamily), Scombridae (family), Scombriformes (order), Pelagiaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0005975 carbohydrate metabolic process; GO:0006006 glucose metabolic process; GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005389_AF2.pdb

hor005389_ESM.pdb

Mass:	373329	Formula:	C142H218N42O41S2
Absent amino acids:	KMTW	Common amino acids:	L
pI:	7.42	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	10
Hydrophobicity:	3.79	Boman Index:	-3802
Half-Life / Aliphatic Index:	20 hour	Aliphatic Index:	90.69
Instability Index:	2505.86	Extinction Coefficient cystines:	1615
Absorbance 280nm:	57.68