General Information

  • ID:  hor005354
  • Uniprot ID:  P43649
  • Protein name:  Stanniocalcin
  • Gene name:  stc
  • Organism:  Oncorhynchus nerka (Sockeye salmon) (Salmo nerka)
  • Family:  Stanniocalcin family
  • Source:  animal
  • Expression:  Produced and secreted by the corpuscles of Stannius.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006811 monoatomic ion transport; GO:0006816 calcium ion transport; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  FSPNSPSDVARCLNGALDVGCGTFACLENSTCDTDGMHDI
  • Length:  40
  • Propeptide:  FSPNSPSDVARCLNGALDVGCGTFACLENSTCDTDGMHDI
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  T29 N-linked (GlcNAc...) asparagine
  • Mutagenesis:  NA

Activity

  • Function:  Its primary function is the prevention of hypercalcemia. Upon release into the circulation, it lowers calcium transport by the gills, thereby reducing its rate of influx from the environment into the extracellular compartment. STC also stimulates phosphate reabsorption by renal proximal tubules. The consequence of this action is increased levels of plasma phosphate, which combines with excess calcium and promotes its disposal into bone and scales.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P43649-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P43649-F1.pdbhor005354_AF2.pdbhor005354_ESM.pdb

Physical Information

Mass: 483037 Formula: C169H262N48O63S5
Absent amino acids: KQWY Common amino acids: D
pI: 3.76 Basic residues: 2
Polar residues: 18 Hydrophobic residues: 11
Hydrophobicity: -5.25 Boman Index: -6084
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 61
Instability Index: 6503.75 Extinction Coefficient cystines: 250
Absorbance 280nm: 6.41

Literature

  • PubMed ID:  3197944
  • Title:  Comparative biochemistry and physiology of teleocalcin from sockeye and coho salmon.