HORDB

ID: hor005335
Uniprot ID: P34166
Protein name: Mating hormone A-factor 2
Gene name: MFA2
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Family: NA
Source: Fungi
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Saccharomyces cerevisiae (species), Saccharomyces (genus), Saccharomycetaceae (family), Saccharomycetales (order), Saccharomycetes (class), Saccharomycotina (subphylum), saccharomyceta, Ascomycota (phylum), Dikarya (subkingdom), Fungi (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0000772 mating pheromone activity; GO:0005186 pheromone activity
GO BP: GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion
GO CC: GO:0005576 extracellular region; GO:0005783 endoplasmic reticulum; GO:0005886 plasma membrane; GO:0016020 membrane

Function: It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005335_AF2.pdb

hor005335_ESM.pdb

Mass:	162211	Formula:	C70H100N14O16S
Absent amino acids:	EHMNQRSTV	Common amino acids:	I
pI:	6.16	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	6
Hydrophobicity:	69.17	Boman Index:	969
Half-Life:	2.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	2 min	Aliphatic Index	105.83
Instability Index:	4768.33	Extinction Coefficient cystines:	6990
Absorbance 280nm:	635.45

PubMed ID: 3542988
Title: Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae.
PubMed ID: 3056940
Title: Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.