General Information

  • ID:  hor005264
  • Uniprot ID:  Q7M427
  • Protein name:  Egg-laying hormone
  • Gene name:  NA
  • Organism:  Aplysia fasciata (Mottled sea hare) (Aplysia brasiliana)
  • Family:  molluscan ELH family
  • Source:  Animal
  • Expression:  Bag cell neurons.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Aplysia (genus), Aplysiidae (family), Aplysioidea (superfamily), Aplysiida (order), Tectipleura, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  ISINQDLKAITDMLLTEQIRERQRYLADLRQRLLEK
  • Length:  36(1-36)
  • Propeptide:  ISINQDLKAITDMLLTEQIRERQRYLADLRQRLLEK
  • Signal peptide:  NA
  • Modification:  T36 Lysine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  ELH acts as a neurotransmitter locally, upon neurons of the abdominal ganglion and as a hormone by diffusing into the circulating hemolymph and modulating the activity of other organs. It specifically causes contraction of smooth muscle in the ovotestis a
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q7M427-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q7M427-F1.pdbhor005264_AF2.pdbhor005264_ESM.pdb

Physical Information

Mass: 500961 Formula: C190H328N58O58S
Absent amino acids: CFGHPVW Common amino acids: L
pI: 9.25 Basic residues: 7
Polar residues: 5 Hydrophobic residues: 13
Hydrophobicity: -61.67 Boman Index: -10968
Half-Life: 20 hour Half-Life Yeast: 30 min
Half-Life E.Coli: >10 hour Aliphatic Index 124.72
Instability Index: 3291.67 Extinction Coefficient cystines: 1490
Absorbance 280nm: 42.57

Literature

  • PubMed ID:  3226961
  • Title:  The bag cell egg-laying hormones of Aplysia brasiliana and Aplysia californica are identical.