HORDB

ID: hor005238
Uniprot ID: P10034
Protein name: Gastrin
Gene name: GAST
Organism: Chinchilla chinchilla (Short-tailed chinchilla) (Chinchilla brevicaudata)
Family: Gastrin/cholecystokinin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Chinchilla (genus), Chinchillidae (family), Hystricomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Sequence: QGPWAEEEAAYGWMDF
Length: 16(18-33)
Propeptide: ELEPQGPPHLGTDLSKKQGPWAEEEAAYGWMDF
Signal peptide: NA
Modification: T1 Pyrrolidone carboxylic acid;T11 Sulfotyrosine;T16 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
Kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005238_AF2.pdb

hor005238_ESM.pdb

Mass:	215475	Formula:	C87H111N19O27S
Absent amino acids:	CHIKLNRSTV	Common amino acids:	AE
pI:	3.33	Basic residues:	0
Polar residues:	3	Hydrophobic residues:	6
Hydrophobicity:	-80.63	Boman Index:	-1753
Half-Life / Aliphatic Index:	0.8 hour	Aliphatic Index:	18.75
Instability Index:	5142.5	Extinction Coefficient cystines:	12490
Absorbance 280nm:	832.67