General Information

  • ID:  hor005234
  • Uniprot ID:  Q9NRI6
  • Protein name:  Putative peptide YY-2
  • Gene name:  PYY2
  • Organism:  Homo sapiens (Human)
  • Family:  NPY family
  • Source:  Human
  • Expression:  Expressed mainly in the testis and prostate.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YPIKPEAPGEDAFLG
  • Length:  15(19-33)
  • Propeptide:  MATVLLALLVYLGALVDAYPIKPEAPGEDAFLG
  • Signal peptide:  MATVLLALLVYLGALVDA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q9NRI6-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005234_AF2.pdbhor005234_ESM.pdb

Physical Information

Mass: 185369 Formula: C75H110N16O23
Absent amino acids: CHMNQRSTVW Common amino acids: P
pI: 3.93 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: -44 Boman Index: -971
Half-Life / Aliphatic Index: 2.8 hour Aliphatic Index: 65.33
Instability Index: 3911.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 106.43

Literature

  • PubMed ID:  10756099
  • Title:  Peptide YY-2 (PYY2) and pancreatic polypeptide-2 (PPY2): species-specific evolution of novel members of the neuropeptide Y gene family.