General Information

  • ID:  hor005208
  • Uniprot ID:  P47214
  • Protein name:  Galanin
  • Gene name:  gal
  • Organism:  Amia calva (Bowfin)
  • Family:  Galanin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Amia (genus), Amiidae (family), Amiiformes (order), Holostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GWTLNSAGYLLGPHAVDNHRSLNDKHGLA
  • Length:  29(1-29)
  • Propeptide:  GWTLNSAGYLLGPHAVDNHRSLNDKHGLA
  • Signal peptide:  NA
  • Modification:  T29 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P47214-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P47214-F1.pdbhor005208_AF2.pdbhor005208_ESM.pdb

Physical Information

Mass: 361407 Formula: C137H209N43O41
Absent amino acids: CEFIMQ Common amino acids: L
pI: 7.8 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 10
Hydrophobicity: -50.34 Boman Index: -4116
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 87.59
Instability Index: 895.52 Extinction Coefficient cystines: 6990
Absorbance 280nm: 249.64

Literature

  • PubMed ID:  7527531
  • Title:  Purification and characterization of galanin from the phylogenetically ancient fish, the bowfin (Amia calva) and dogfish (Scyliorhinus canicula).