General Information

  • ID:  hor005207
  • Uniprot ID:  P47215
  • Protein name:  Galanin
  • Gene name:  GAL
  • Organism:  Alligator mississippiensis (American alligator)
  • Family:  Galanin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Alligator (genus), Alligatorinae (subfamily), Alligatoridae (family), Crocodylia (order), Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GWTLNSAGYLLGPHAIDNHRSFNEKHGIA
  • Length:  29(1-29)
  • Propeptide:  GWTLNSAGYLLGPHAIDNHRSFNEKHGIA
  • Signal peptide:  NA
  • Modification:  T29 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P47215-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P47215-F1.pdbhor005207_AF2.pdbhor005207_ESM.pdb

Physical Information

Mass: 367613 Formula: C142H211N43O41
Absent amino acids: CMQV Common amino acids: G
pI: 7.8 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 10
Hydrophobicity: -50.34 Boman Index: -4031
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 77.59
Instability Index: 1413.79 Extinction Coefficient cystines: 6990
Absorbance 280nm: 249.64

Literature

  • PubMed ID:  7524049
  • Title:  Purification and primary structure of galanin from the alligator stomach.