HORDB

ID: hor005190
Uniprot ID: P31234
Protein name: Galanin
Gene name: GAL
Organism: Ovis aries (Sheep)
Family: Galanin family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion.
Mechanism: NA
Cross BBB: NA
Target: GALR3, GALR1
Target Unid: W5PXX9, W5P2L8
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P31234-F1.pdb

hor005190_AF2.pdb

hor005190_ESM.pdb

Mass:	368515	Formula:	C143H210N44O40
Absent amino acids:	CEMQV	Common amino acids:	GHL
pI:	7.87	Basic residues:	6
Polar residues:	10	Hydrophobic residues:	10
Hydrophobicity:	-51.72	Boman Index:	-4024
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	77.59
Instability Index:	1413.79	Extinction Coefficient cystines:	6990
Absorbance 280nm:	249.64