General Information

  • ID:  hor005177
  • Uniprot ID:  P31886
  • Protein name:  Gastrin-releasing peptide
  • Gene name:  GRP
  • Organism:  Alligator mississippiensis (American alligator)
  • Family:  Bombesin/neuromedin-B/ranatensin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Alligator (genus), Alligatorinae (subfamily), Alligatoridae (family), Crocodylia (order), Archosauria, Archelosauria, Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0090277 positive regulation of peptide hormone secretion; GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0031410 cytoplasmic vesicle; GO:0034774 secretory granule lumen

Sequence Information

  • Sequence:  APAPSGGGSAPLAKIYPRGSHWAVGHLM
  • Length:  28(1-28)
  • Propeptide:  APAPSGGGSAPLAKIYPRGSHWAVGHLM
  • Signal peptide:  NA
  • Modification:  T28 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excited smooth muscle
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P31886-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P31886-F1.pdbhor005177_AF2.pdbhor005177_ESM.pdb

Physical Information

Mass: 326799 Formula: C126H193N37O33S
Absent amino acids: CDEFNQT Common amino acids: AG
pI: 10.45 Basic residues: 4
Polar residues: 9 Hydrophobic residues: 10
Hydrophobicity: -2.14 Boman Index: -290
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 70
Instability Index: 3907.14 Extinction Coefficient cystines: 6990
Absorbance 280nm: 258.89

Literature

  • PubMed ID:  8101369
  • Title:  Neuroendocrine peptides (NPY, GRP, VIP, somatostatin) from the brain and stomach of the alligator.