General Information

  • ID:  hor005166
  • Uniprot ID:  P42706
  • Protein name:  Thrombopoietin
  • Gene name:  THPO
  • Organism:  Sus scrofa (Pig)
  • Family:  EPO/TPO family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005125 cytokine activity; GO:0005179 hormone activity
  • GO BP:  GO:0001934 positive regulation of protein phosphorylation; GO:0038163 thrombopoietin-mediated signaling pathway; GO:0045654 positive regulation of megakaryocyte differentiation; GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; GO:0070374 positive regulation of ERK1 and ERK2 cascade
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  SPAPPACDPRLLNKLLRDDHVLHGRL
  • Length:  26
  • Propeptide:  SPAPPACDPRLLNKLLRDDHVLHGRL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • Mechanism:  This protein binds to and activates the c-mpl protein
  • Cross BBB:  NA
  • Target:  MPL
  • Target Unid:  K7GPS1
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P42706-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P42706-F1.pdbhor005166_AF2.pdbhor005166_ESM.pdb

Physical Information

Mass: 335051 Formula: C127H211N41O35S
Absent amino acids: EFIMQTWY Common amino acids: L
pI: 8.56 Basic residues: 6
Polar residues: 4 Hydrophobic residues: 9
Hydrophobicity: -47.31 Boman Index: -5643
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 108.85
Instability Index: 8681.54 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8202154
  • Title:  Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.