General Information

  • ID:  hor005160
  • Uniprot ID:  P20056
  • Protein name:  Neuromedin-U-25
  • Gene name:  NA
  • Organism:  Rana temporaria (European common frog)
  • Family:  NmU family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rana (subgenus), Rana (genus), Ranidae (family), Ranoidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006940 regulation of smooth muscle contraction; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  LKPDEELQGPGGVLSRGYFVFRPRN
  • Length:  25(1-25)
  • Propeptide:  LKPDEELQGPGGVLSRGYFVFRPRN
  • Signal peptide:  NA
  • Modification:  T25 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates uterine smooth muscle contraction and causes selective vasoconstriction.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P20056-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P20056-F1.pdbhor005160_AF2.pdbhor005160_ESM.pdb

Physical Information

Mass: 326046 Formula: C128H199N37O36
Absent amino acids: ACHIMTW Common amino acids: G
pI: 9.3 Basic residues: 4
Polar residues: 7 Hydrophobic residues: 7
Hydrophobicity: -72 Boman Index: -5581
Half-Life: 5.5 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 70
Instability Index: 4172.4 Extinction Coefficient cystines: 1490
Absorbance 280nm: 62.08

Literature

  • PubMed ID:  2592357
  • Title:  The distribution, purification, and pharmacological action of an amphibian neuromedin U.