General Information

  • ID:  hor005156
  • Uniprot ID:  P0CV87
  • Protein name:  C-type natriuretic peptide
  • Gene name:  NA
  • Organism:  Crotalus atrox (Western diamondback rattlesnake)
  • Family:  natriuretic peptide family
  • Source:  Animal
  • Expression:  Venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Crotalus (genus), Crotalinae (subfamily), Viperidae (family), Colubroidea (superfamily), Serpentes (infraorder), Toxicofera, Episquamata, Unidentata, Bifurcata, Squamata (order), Lepidosauria (class), Sauria, Sauropsida, Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AKKRAGNGCFGLKLDRIGSMSGLGC
  • Length:  25(1-25)
  • Propeptide:  AKKRAGNGCFGLKLDRIGSMSGLGC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It exhibits hypotensive and vasodepressor activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45925
  • Structure ID:  AF-P0CV87-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P0CV87-F1.pdbhor005156_AF2.pdbhor005156_ESM.pdb

Physical Information

Mass: 296830 Formula: C106H183N35O31S3
Absent amino acids: EHPQTVWY Common amino acids: G
pI: 10.51 Basic residues: 5
Polar residues: 11 Hydrophobic residues: 7
Hydrophobicity: -10 Boman Index: -3182
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 70.4
Instability Index: 2100 Extinction Coefficient cystines: 125
Absorbance 280nm: 5.21

Literature

  • PubMed ID:  19371136
  • Title:  Exploring the venom proteome of the western diamondback rattlesnake, Crotalus atrox, via snake venomics and combinatorial peptide ligand library approaches.