General Information

  • ID:  hor005150
  • Uniprot ID:  P83628
  • Protein name:  Insulin-like growth factor-binding protein 2
  • Gene name:  igfbp2
  • Organism:  Oncorhynchus tshawytscha (Chinook salmon) (Salmo tshawytscha)
  • Family:  NA
  • Source:  animal
  • Expression:  Up-regulated by growth hormone treatment and down-regulated by fasting.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Oncorhynchus (genus), Salmoninae (subfamily), Salmonidae (family), Salmoniformes (order), Protacanthopterygii, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005520 insulin-like growth factor binding; GO:0019838 growth factor binding
  • GO BP:  GO:0008150 biological_process
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DLVFYCPKCTAERQTACPKL
  • Length:  20(1-20)
  • Propeptide:  DLVFYCPKCTAERQTACPKL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the intera
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P83628-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P83628-F1.pdbhor005150_AF2.pdbhor005150_ESM.pdb

Physical Information

Mass: 262580 Formula: C100H160N26O29S3
Absent amino acids: GHIMNSW Common amino acids: C
pI: 8.04 Basic residues: 3
Polar residues: 6 Hydrophobic residues: 6
Hydrophobicity: -15 Boman Index: -2805
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 63.5
Instability Index: 8871.5 Extinction Coefficient cystines: 1615
Absorbance 280nm: 85

Literature

  • PubMed ID:  12765649
  • Title:  Purification of a 41-kDa insulin-like growth factor binding protein from serum of chinook salmon, Oncorhynchus tshawytscha.