HORDB

ID: hor005149
Uniprot ID: P07448
Protein name: Dentinal fluid transport-stimulating peptide,DFT-stimulating peptide
Gene name: NA
Organism: Rattus norvegicus (Rat)
Family: NA
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: NA

Function: This peptide stimulates the transport of dentinal fluid, which is important for the prevention of dental caries.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: sIGF-I???0.5ng/ml,hIGF-I:6.0ng/ml,hIGF-II:3.0ng/ml
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P07448-F1.pdb

hor005149_AF2.pdb

hor005149_ESM.pdb

Mass:	250444	Formula:	C93H145N29O31
Absent amino acids:	CFMY	Common amino acids:	G
pI:	5.55	Basic residues:	3
Polar residues:	6	Hydrophobic residues:	6
Hydrophobicity:	-91	Boman Index:	-4297
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.5
Instability Index:	5690	Extinction Coefficient cystines:	5500
Absorbance 280nm:	289.47

PubMed ID: 3815601
Title: Isolation and amino acid sequence of dentinal fluid transport-stimulating peptide from rat parotid glands.
PubMed ID: 5297832
Title: Isolation and amino acid sequence of dentinal fluid transport-stimulating peptide from rat parotid glands.