General Information

  • ID:  hor005140
  • Uniprot ID:  P83586
  • Protein name:  Pigment-dispersing hormone B
  • Gene name:  NA
  • Organism:  Faxonius limosus (Spinycheek crayfish) (Orconectes limosus)
  • Family:  Arthropod PDH family
  • Source:  Animal
  • Expression:  Eyestalk sinus gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Faxonius (genus), Cambarinae (subfamily), Cambaridae (family), Astacoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission
  • GO CC:  GO:0005576 extracellular region; GO:0045202 synapse

Sequence Information

  • Sequence:  NSELINAILGSPTLFGEV
  • Length:  18(1-18)
  • Propeptide:  NSELINAILGSPTLFGEV
  • Signal peptide:  NA
  • Modification:  T18 Valine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It may causes the migration of the distal retinal pigment into the proximal end of the pigment chromatophore cells and thus decreases the amount of light entering the retinulas. It may also function as a neurotransmitter and/or neuromodulator
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P83586-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P83586-F1.pdbhor005140_AF2.pdbhor005140_ESM.pdb

Physical Information

Mass: 217753 Formula: C84H136N20O28
Absent amino acids: CDHKMQRWY Common amino acids: L
pI: 3.61 Basic residues: 0
Polar residues: 7 Hydrophobic residues: 8
Hydrophobicity: 58.33 Boman Index: -96
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 130
Instability Index: 5056.67 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  14981133
  • Title:  Identification of neuropeptides from the sinus gland of the crayfish Orconectes limosus using nanoscale on-line liquid chromatography tandem mass spectrometry.