General Information

  • ID:  hor005139
  • Uniprot ID:  P01206
  • Protein name:  Melanotropin beta
  • Gene name:  NA
  • Organism:  Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
  • Family:  POMC family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  BZIBYKMGHFRWGAPMDK
  • Length:  18
  • Propeptide:  BZIBYKMGHFRWGAPMDK
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It increases the pigmentation of skin by increasing melanin production in melanocytes
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005139_AF2.pdbhor005139_ESM.pdb

Physical Information

Mass: 208655 Formula: C85H119N23O16S2
Absent amino acids: CELNQSTV Common amino acids: GKM
pI: 10.24 Basic residues: 4
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: -59.44 Boman Index: -2092
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index 27.22
Instability Index: 4271.11 Extinction Coefficient cystines: 6990
Absorbance 280nm: 411.18

Literature

  • PubMed ID:  4452470
  • Title:  A beta-MSH in the pituitary gland of the spotted dogfish (Scyliorhinus canicula): isolation and structure.