General Information

  • ID:  hor005138
  • Uniprot ID:  P01202
  • Protein name:  Melanotropin beta
  • Gene name:  NA
  • Organism:  Equus caballus (Horse)
  • Family:  POMC family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Equus (genus), Equidae (family), Perissodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DEGPYKMEHFRWGSPRKD
  • Length:  18
  • Propeptide:  DEGPYKMEHFRWGSPRKD
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It increases the pigmentation of skin by increasing melanin production in melanocytes
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P01202-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P01202-F1.pdbhor005138_AF2.pdbhor005138_ESM.pdb

Physical Information

Mass: 253885 Formula: C99H143N29O29S
Absent amino acids: ACILNQTV Common amino acids: DEGKPR
pI: 7.54 Basic residues: 5
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -201.67 Boman Index: -7066
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 6388.89 Extinction Coefficient cystines: 6990
Absorbance 280nm: 411.18

Literature

  • PubMed ID:  13723150
  • Title:  The isolation and structure of beta-melanocyte-stimulating hormone from horse pituitary glands.