General Information

  • ID:  hor005108
  • Uniprot ID:  P84672
  • Protein name:  Pyrokinin 5
  • Gene name:  NA
  • Organism:  Derocalymma cruralis (African cockroach)
  • Family:  pyrokinin family
  • Source:  Animal
  • Expression:  Expressed in abdominal perisympathetic organs and abdominal ganglia.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Derocalymma (genus), Perisphaerinae (subfamily), Blaberidae (family), Blaberoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DGDMSGEGKGMWFGPRL
  • Length:  17(1-17)
  • Propeptide:  DGDMSGEGKGMWFGPRL
  • Signal peptide:  NA
  • Modification:  T17 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P84672-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P84672-F1.pdbhor005108_AF2.pdbhor005108_ESM.pdb

Physical Information

Mass: 212563 Formula: C79H118N22O25S2
Absent amino acids: ACHINQTVY Common amino acids: G
pI: 4.37 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 3
Hydrophobicity: -81.18 Boman Index: -2849
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 22.94
Instability Index: 1640 Extinction Coefficient cystines: 5500
Absorbance 280nm: 343.75

Literature

  • PubMed ID:  19257902
  • Title:  A proteomic approach for studying insect phylogeny: CAPA peptides of ancient insect taxa (Dictyoptera, Blattoptera) as a test case.