HORDB

ID: hor005076
Uniprot ID: P01207
Protein name: Melanotropin beta
Gene name: NA
Organism: Squalus acanthias (Spiny dogfish)
Family: POMC family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Squalus (genus), Squalidae (family), Squaliformes (order), Squalomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01207-F1.pdb

hor005076_AF2.pdb

hor005076_ESM.pdb

Mass:	220685	Formula:	C91H123N23O25
Absent amino acids:	ACEIMNQT	Common amino acids:	D
pI:	5.49	Basic residues:	3
Polar residues:	4	Hydrophobic residues:	5
Hydrophobicity:	-86.88	Boman Index:	-3570
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	42.5
Instability Index:	5073.13	Extinction Coefficient cystines:	6990
Absorbance 280nm:	466

PubMed ID: 4375978
Title: Structural studies of alpha-melanocyte-stimulating hormone and a novel beta-melanocyte-stimulating hormone from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.