General Information

  • ID:  hor005071
  • Uniprot ID:  P20404
  • Protein name:  Locustapyrokinin-1
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  pyrokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QDSGDGWPQQPFVPRL
  • Length:  16(1-16)
  • Propeptide:  QDSGDGWPQQPFVPRL
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T16 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P20404-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P20404-F1.pdbhor005071_AF2.pdbhor005071_ESM.pdb

Physical Information

Mass: 209472 Formula: C82H119N23O25
Absent amino acids: ACEHIKMNTY Common amino acids: PQ
pI: 4.11 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: -115.63 Boman Index: -3623
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 42.5
Instability Index: 9663.75 Extinction Coefficient cystines: 5500
Absorbance 280nm: 366.67

Literature

  • PubMed ID:  2026322
  • Title:  Isolation, primary structure, and synthesis of locustapyrokinin: a myotropic peptide of Locusta migratoria.