General Information

  • ID:  hor005055
  • Uniprot ID:  P46980
  • Protein name:  Myoactive tetradecapeptide
  • Gene name:  NA
  • Organism:  Amynthas vittatus (Earthworm) (Pheretima vittata)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Amynthas (genus), Megascolecidae (family), Megascolecida (suborder), Crassiclitellata (order), Oligochaeta (subclass), Clitellata (class), Annelida (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GFRDGSADRISHGF
  • Length:  14(1-14)
  • Propeptide:  GFRDGSADRISHGF
  • Signal peptide:  NA
  • Modification:  T14 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Has a stimulative effect on the contraction of gut muscles.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005055_AF2.pdbhor005055_ESM.pdb

Physical Information

Mass: 175367 Formula: C65H96N22O21
Absent amino acids: CEKLMNPQTVWY Common amino acids: G
pI: 7.55 Basic residues: 3
Polar residues: 5 Hydrophobic residues: 4
Hydrophobicity: -72.14 Boman Index: -4323
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 35
Instability Index: -957.14 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8532604
  • Title:  A novel gut tetradecapeptide isolated from the earthworm, Eisenia foetida.