General Information

  • ID:  hor005027
  • Uniprot ID:  P42717
  • Protein name:  Waspkinin
  • Gene name:  NA
  • Organism:  Parapolybia indica (Lesser paper wasp)
  • Family:  Bradykinin-related peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Parapolybia (genus), Ropalidiini (tribe), Polistinae (subfamily), Vespidae (family), Vespoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0006952 defense response; GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QZKRPPGFSPFRK
  • Length:  13(1-13)
  • Propeptide:  QZKRPPGFSPFRK
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Induces smooth muscle contraction. May target bradykinin receptors (BDKRB). May cause hypotension.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005027_AF2.pdbhor005027_ESM.pdb

Physical Information

Mass: 164088 Formula: C67H103N21O14
Absent amino acids: ACDEHILMNTVWY Common amino acids: P
pI: 12.53 Basic residues: 4
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -159.23 Boman Index: -4298
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 11101.54 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  NA
  • Title:  Isolation and sequential analysis of peptides on the venom sac of Parapolybia indica.