General Information

  • ID:  hor005024
  • Uniprot ID:  P83109
  • Protein name:  Antidiuretic factor B
  • Gene name:  NA
  • Organism:  Tenebrio molitor (Yellow mealworm beetle)
  • Family:  NA
  • Source:  animal
  • Expression:  Brain. Appears to be mainly expressed in two pairs of bilaterally symmetrical cells in the protocerebrum.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Tenebrio (genus), Tenebrioninae (subfamily), Tenebrionidae (family), Tenebrionoidea (superfamily), Cucujiformia (infraorder), Polyphaga (suborder), Coleoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YDDGSYKPHIYGF
  • Length:  13(1-13)
  • Propeptide:  YDDGSYKPHIYGF
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibitor of fluid secretion by Malpighian tubules. Uses cGMP as second messenger. May function as an antidiuretic hormone.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 240 pM
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005024_AF2.pdbhor005024_ESM.pdb

Physical Information

Mass: 177589 Formula: C74H96N16O22
Absent amino acids: ACELMNQRTVW Common amino acids: Y
pI: 5.41 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 2
Hydrophobicity: -106.92 Boman Index: -2169
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 30
Instability Index: 4891.54 Extinction Coefficient cystines: 4470
Absorbance 280nm: 372.5

Literature

  • PubMed ID:  12576082
  • Title:  Isolation, identification and localization of a second beetle antidiuretic peptide.