General Information

  • ID:  hor005020
  • Uniprot ID:  P01147
  • Protein name:  Urotensin-2
  • Gene name:  NA
  • Organism:  Gillichthys mirabilis (Long-jawed mudsucker)
  • Family:  Urotensin-2 family
  • Source:  animal
  • Expression:  teleost caudal neurosecretory system
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Gillichthys (genus), Gobionellinae (subfamily), Gobiidae (family), Gobioidei (suborder), Gobiiformes (order), Gobiaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AGTADCFWKYCV
  • Length:  12
  • Propeptide:  AGTADCFWKYCV
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  It has a suggested role in osmoregulation and as a corticotropin-releasing factor.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  6-11
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005020_AF2.pdbhor005020_ESM.pdb

Physical Information

Mass: 155997 Formula: C62H86N14O17S2
Absent amino acids: EHILMNPQRS Common amino acids: AC
pI: 6.06 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 5
Hydrophobicity: 40.83 Boman Index: -51
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 40.83
Instability Index: -1126.67 Extinction Coefficient cystines: 7115
Absorbance 280nm: 646.82

Literature

  • PubMed ID:  6107911
  • Title:  Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes.