General Information

  • ID:  hor004968
  • Uniprot ID:  P85873
  • Protein name:  Wasp kinin PMM1
  • Gene name:  NA
  • Organism:  Polistes major (Neotropical social wasp)
  • Family:  Bradykinin-related peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Polistes (genus), Polistini (tribe), Polistinae (subfamily), Vespidae (family), Vespoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0006952 defense response; GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  KRRPPGFTPFR
  • Length:  11(1-11)
  • Propeptide:  KRRPPGFTPFR
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Induces relaxation of arterial smooth muscle, by targeting bradykinin receptors (BDKRB) and may cause hypotension. (By similarity)
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004968_AF2.pdbhor004968_ESM.pdb

Physical Information

Mass: 153713 Formula: C63H99N21O13
Absent amino acids: ACDEHILMNQSVWY Common amino acids: PR
pI: 12.81 Basic residues: 4
Polar residues: 2 Hydrophobic residues: 2
Hydrophobicity: -160.91 Boman Index: -4598
Half-Life / Aliphatic Index: 1.3 hour Aliphatic Index: 0
Instability Index: 14332.73 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  17559065
  • Title:  Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major.