General Information

  • ID:  hor004954
  • Uniprot ID:  P81749
  • Protein name:  Gonadoliberin-1
  • Gene name:  gnrh1
  • Organism:  Clupea pallasii (Pacific herring)
  • Family:  GnRH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Clupea (genus), Clupeinae (subfamily), Clupeidae (family), Clupeoidei (suborder), Clupeiformes (order), Clupei (subcohort), Otomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QHWSHGLSPG
  • Length:  10(1-10)
  • Propeptide:  QHWSHGLSPG
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the secretion of gonadotropins.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004954_AF2.pdbhor004954_ESM.pdb

Physical Information

Mass: 126589 Formula: C49H68N16O14
Absent amino acids: ACDEFIKMNRTVY Common amino acids: GHS
pI: 7.72 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 2
Hydrophobicity: -110 Boman Index: -1253
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: 3969 Extinction Coefficient cystines: 5500
Absorbance 280nm: 611.11

Literature

  • PubMed ID:  10650929
  • Title:  Primary structure and function of three gonadotropin-releasing hormones, including a novel form, from an ancient teleost, herring.