HORDB

ID: hor004924
Uniprot ID: P81626
Protein name: Hypertrehalosaemic hormone
Gene name: NA
Organism: Locusta migratoria (Migratory locust)
Family: AKH/HRTH/RPCH family
Source: Animal
Expression: Synthesized in the neurosecretory cells of the brain, and transported to the storage lobe of the corpora cardiaca.
Disease: NA
Comments: NA
Taxonomy: Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Function: The in vivo function of this peptide is unknown. Has no adipokinetic or hypertrehalosaemic activity in locusts. Has hypertrehalosaemic activity in the cockcroach P.americana.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004924_AF2.pdb

hor004924_ESM.pdb

Mass:	138302	Formula:	C55H79N15O17
Absent amino acids:	ACEGHIKLMNY	Common amino acids:	S
pI:	6.34	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	3
Hydrophobicity:	-93	Boman Index:	-2920
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	29
Instability Index:	6851	Extinction Coefficient cystines:	5500
Absorbance 280nm:	611.11