General Information

  • ID:  hor004899
  • Uniprot ID:  P85141
  • Protein name:  Gamma-conopressin vil
  • Gene name:  NA
  • Organism:  Conus villepinii (Villepin's cone)
  • Family:  Vasopressin/oxytocin family
  • Source:  Animal
  • Expression:  Expressed by the venom duct.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Dauciconus (subgenus), Conus (genus), Conidae (family), Conoidea (superfamily), Neogastropoda (order), Caenogastropoda (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0046872 metal ion binding; GO:0090729 toxin activity
  • GO BP:  GO:0035821 modulation of process of another organism
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CLIQDCPEG
  • Length:  9(1-9)
  • Propeptide:  CLIQDCPEG
  • Signal peptide:  NA
  • Modification:  T8 4-carboxyglutamate;T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Binds calcium
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45663
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004899_AF2.pdbhor004899_ESM.pdb

Physical Information

Mass: 112001 Formula: C39H64N10O15S2
Absent amino acids: AFHKMNRSTVWY Common amino acids: C
pI: 3.55 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: 8.89 Boman Index: -773
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 86.67
Instability Index: 9240 Extinction Coefficient cystines: 125
Absorbance 280nm: 15.63

Literature

  • PubMed ID:  17331075
  • Title:  A vasopressin/oxytocin-related conopeptide with gamma-carboxyglutamate at position 8.