General Information

  • ID:  hor004898
  • Uniprot ID:  P24816
  • Protein name:  Gastrin/cholecystokinin-like peptide D1
  • Gene name:  NA
  • Organism:  Nephrops norvegicus (Norway lobster)
  • Family:  Gastrin/cholecystokinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Nephrops (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SEGGQDFWL
  • Length:  9(1-9)
  • Propeptide:  SEGGQDFWL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Control digestion processes in crustaceans.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004898_AF2.pdbhor004898_ESM.pdb

Physical Information

Mass: 118096 Formula: C47H63N11O16
Absent amino acids: ACHIKMNPRTVY Common amino acids: G
pI: 3.55 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -71.11 Boman Index: -1236
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: 7073.33 Extinction Coefficient cystines: 5500
Absorbance 280nm: 687.5

Literature

  • PubMed ID:  1747388
  • Title:  Structure and biological activity of crustacean gastrointestinal peptides identified with antibodies to gastrin/cholecystokinin.