General Information

  • ID:  hor004883
  • Uniprot ID:  P85514
  • Protein name:  Neuropeptide NPF-2
  • Gene name:  Neuropeptide
  • Organism:  Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora decemlineata)
  • Family:  NPY family
  • Source:  Animal
  • Expression:  Found in the brain of non-diapausing beetles, but not in diapausing beetles.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Leptinotarsa (genus), Doryphorini (tribe), Chrysomelinae (subfamily), Chrysomelidae (family), Chrysomeloidea (superfamily), Cucujiformia (infraorder), Polyphaga (suborder), Coleoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APSLRLRF
  • Length:  8(1-8)
  • Propeptide:  APSLRLRF
  • Signal peptide:  NA
  • Modification:  T8 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be involved in the regulation of adult diapause.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004883_AF2.pdbhor004883_ESM.pdb

Physical Information

Mass: 108419 Formula: C44H74N14O10
Absent amino acids: CDEGHIKMNQTVWY Common amino acids: LR
pI: 12.5 Basic residues: 2
Polar residues: 1 Hydrophobic residues: 4
Hydrophobicity: 10 Boman Index: -1861
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 110
Instability Index: 10505 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8814784
  • Title:  Insect neuropeptide F (NPF)-related peptides: isolation from Colorado potato beetle (Leptinotarsa decemlineata) brain.
  • PubMed ID:  15081426
  • Title:   Diapausing Colorado potato beetles are devoid of short neuropeptide F I and II.