General Information

  • ID:  hor004874
  • Uniprot ID:  P84260
  • Protein name:  Hypertrehalosaemic factor 1
  • Gene name:  NA
  • Organism:  Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora decemlineata)
  • Family:  AKH/HRTH/RPCH family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Leptinotarsa (genus), Doryphorini (tribe), Chrysomelinae (subfamily), Chrysomelidae (family), Chrysomeloidea (superfamily), Cucujiformia (infraorder), Polyphaga (suborder), Coleoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QVNFSPNW
  • Length:  8(1-8)
  • Propeptide:  QVNFSPNW
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T8 Tryptophan amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Elevate the level of trehalose in the hemolymph
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004874_AF2.pdbhor004874_ESM.pdb

Physical Information

Mass: 111610 Formula: C46H62N12O13
Absent amino acids: ACDEGHIKLMRTY Common amino acids: N
pI: 6.11 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -85 Boman Index: -1287
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 36.25
Instability Index: 2250 Extinction Coefficient cystines: 5500
Absorbance 280nm: 785.71

Literature

  • PubMed ID:  2576128
  • Title:  The metabolic neuropeptides of the corpus cardiacum from the potato beetle and the American cockroach are identical.