General Information

  • ID:  hor004824
  • Uniprot ID:  P58649
  • Protein name:  Cardioactive peptide Ocp-3/Ocp-4
  • Gene name:  N/A
  • Organism:  Callistoctopus minor (Octopus) (Octopus minor)
  • Family:  NA
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Callistoctopus (genus), Octopodidae (family), Incirrata (suborder), Octopoda (order), Octopodiformes (superorder), Coleoidea (subclass), Cephalopoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GSWD
  • Length:  4(1-4)
  • Propeptide:  GSWD
  • Signal peptide:  NA
  • Modification:  T2 D-serine (Ser)
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Cardioactive; has both positive chronotropic and inotropic effects on the heart. Ocp-4 is a 1000 time less active than Ocp-3.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004824_AF2.pdbhor004824_ESM.pdb

Physical Information

Mass: 51714 Formula: C20H25N5O8
Absent amino acids: ACEFHIKLMNPQRTVY Common amino acids: DGSW
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -140 Boman Index: -885
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: 750 Extinction Coefficient cystines: 5500
Absorbance 280nm: 1833.33

Literature

  • PubMed ID:  10876044
  • Title:  Cardioactive peptides isolated from the brain of a Japanese octopus, Octopus minor.