General Information

  • ID:  hor004807
  • Uniprot ID:  E2ADX8
  • Protein name:  Allatostatin A3
  • Gene name:  EAG_13122
  • Organism:  Camponotus floridanus (Florida carpenter ant)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  Allatostatins A1, A2 and A3 are expressed in brain, antennal lobes, optical lobes, gnathal ganglia, the retrocerebral complex and thoracic, abdominal and ventral ganglia. Allatostain A4 is expressed in brain (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Camponotus (genus), Camponotini (tribe), Formicinae (subfamily), Formicidae (family), Formicoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  LRDYRFGI
  • Length:  8(98-105)
  • Propeptide:  MKTSSLIAMRLIIFYLLSVVGRSTAAVEEAPASSLHIPRLNPLSSNLEYDEPSEKRAYAYISEYKRLPLYNFGIGKRWIDNSEDKRTRPFSFGIGKRLRDYRFGIGKRNSGYRPLGMDFSVDNMDFHSREDNLDDFIDDKRGGQPFSFGIGKRGWKLPMGEMAVSGRRLNDVVGPKYLLGLGKGLSENENLIQ
  • Signal peptide:  MKTSSLIAMRLIIFYLLSVVGRSTA
  • Modification:  T8 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter or neuromodulator.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E2ADX8-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004807_AF2.pdbhor004807_ESM.pdb

Physical Information

Mass: 116424 Formula: C48H74N14O12
Absent amino acids: ACEHKMNPQSTVW Common amino acids: R
pI: 9.35 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -38.75 Boman Index: -2494
Half-Life: 5.5 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 97.5
Instability Index: 107.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  25641051
  • Title:  Neuropeptidomics of the Carpenter Ant Camponotus Floridanus