General Information

  • ID:  hor004804
  • Uniprot ID:  P0DM71
  • Protein name:  Protopolybiakinin-II
  • Gene name:  NA
  • Organism:  Protopolybia exigua (Neotropical social wasp)
  • Family:  Bradykinin-related peptide family
  • Source:  Animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Protopolybia (genus), Epiponini (tribe), Polistinae (subfamily), Vespidae (family), Vespoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0035821 modulation of process of another organism
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DKNKKPIWMAGFPGFTPIR
  • Length:  19(1-19)
  • Propeptide:  DKNKKPIWMAGFPGFTPIR
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Degranulation of mast cells
  • Mechanism:  Negative results: does not provoke rat ileum muscle constriction and does not show algesic effects.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P0DM71-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P0DM71-F1.pdbhor004804_AF2.pdbhor004804_ESM.pdb

Physical Information

Mass: 252487 Formula: C104H159N27O24S
Absent amino acids: CEHLQSVY Common amino acids: KP
pI: 11.08 Basic residues: 4
Polar residues: 4 Hydrophobic residues: 6
Hydrophobicity: -63.68 Boman Index: -2533
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 46.32
Instability Index: 4259.47 Extinction Coefficient cystines: 5500
Absorbance 280nm: 305.56

Literature

  • PubMed ID:  16815592
  • Title:  Two New Bradykinin-Related Peptides From the Venom of the Social Wasp Protopolybia Exigua (Saussure)