General Information

  • ID:  hor004803
  • Uniprot ID:  NA
  • Protein name:  Protopolybiakinin-I
  • Gene name:  NA
  • Organism:  Protopolybia exigua
  • Family:  Bradykinin-related peptide family
  • Source:  Animal
  • Expression:  venom
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DKNKKPIRVGGRRPPGFTR
  • Length:  19
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Caused potent constriction of the isolated rat ileum muscles , degranulation of mast cells and algesic effects. Protopolybiakinin-I is a B2-type agonist
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  3.8*10(-6)M
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004803_AF2.pdbhor004803_ESM.pdb

Physical Information

Mass: 250078 Formula: C95H163N35O24
Absent amino acids: ACEHLMQSWY Common amino acids: R
pI: 12.52 Basic residues: 7
Polar residues: 5 Hydrophobic residues: 3
Hydrophobicity: -167.89 Boman Index: -7950
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 35.79
Instability Index: 6594.74 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  16815592
  • Title:  Two New Bradykinin-Related Peptides From the Venom of the Social Wasp Protopolybia Exigua (Saussure)