HORDB

General Information

ID: hor004796
Uniprot ID: NA
Protein name: fulvonin
Gene name: NA
Organism: solitary wasp
Family: Bradykinin-related peptide family
Source: Animal
Expression: venom
Disease: NA
Comments: NA
Taxonomy: NA
GO MF: NA
GO BP: NA
GO CC: NA

Sequence Information

Sequence: SIVLRGKAPFR
Length: 11
Propeptide: NA
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Inhibits angiotensin-converting enzyme (ACE) and targets B1 bradykinin receptor (BDKRB1). In vivo, induces hyperalgesic effects in living rats after intraplantar injection.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: 352.5+/-64.7nM
ED50: NA
Kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004796_AF2.pdb

hor004796_ESM.pdb

Physical Information

Mass:	142206	Formula:	C57H98N18O13
Absent amino acids:	CDEHMNQTWY	Common amino acids:	R
pI:	12.52	Basic residues:	3
Polar residues:	2	Hydrophobic residues:	5
Hydrophobicity:	12.73	Boman Index:	-1918
Half-Life / Aliphatic Index:	1.9 hour	Aliphatic Index:	106.36
Instability Index:	3846.36	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

Literature

PubMed ID: 19716363
Title: Bradykinin-related peptides in the venom of the solitary wasp Cyphononyx fulvognathus.