General Information

  • ID:  hor004796
  • Uniprot ID:  NA
  • Protein name:  fulvonin
  • Gene name:  NA
  • Organism:  solitary wasp
  • Family:  Bradykinin-related peptide family
  • Source:  animal
  • Expression:  venom
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  SIVLRGKAPFR
  • Length:  11
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibits angiotensin-converting enzyme (ACE) and targets B1 bradykinin receptor (BDKRB1). In vivo, induces hyperalgesic effects in living rats after intraplantar injection.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: 352.5+/-64.7nM
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004796_AF2.pdbhor004796_ESM.pdb

Physical Information

Mass: 142206 Formula: C57H98N18O13
Absent amino acids: CDEHMNQTWY Common amino acids: R
pI: 12.52 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 5
Hydrophobicity: 12.73 Boman Index: -1918
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 106.36
Instability Index: 3846.36 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19716363
  • Title:  Bradykinin-related peptides in the venom of the solitary wasp Cyphononyx fulvognathus.