General Information

  • ID:  hor004782
  • Uniprot ID:  NA
  • Protein name:  ranakinestatin-PPF
  • Gene name:  NA
  • Organism:  Pelophylax plancyi fukienensis
  • Family:  Bradykinin-related peptide family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  DYTIRTRLHQGLSRKIV
  • Length:  17
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Inhibited the dose-dependent relaxation effect of bradykinin
  • Mechanism:  Binding to bradykinin receptor B2
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004782_AF2.pdbhor004782_ESM.pdb

Physical Information

Mass: 234197 Formula: C90H154N30O25
Absent amino acids: ACEFMNPW Common amino acids: R
pI: 11.43 Basic residues: 5
Polar residues: 5 Hydrophobic residues: 5
Hydrophobicity: -62.94 Boman Index: -5325
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 108.82
Instability Index: 575.88 Extinction Coefficient cystines: 1490
Absorbance 280nm: 93.13

Literature

  • PubMed ID:  25161395
  • Title:  Ranakinestatin-PPF From the Skin Secretion of the Fukien Gold-Striped Pond Frog, Pelophylax Plancyi Fukienensis: A Prototype of a Novel Class of Bradykinin B2 Receptor Antagonist Peptide From Ranid Frogs