General Information

  • ID:  hor004773
  • Uniprot ID:  P34964
  • Protein name:  Neuromedin-U-25
  • Gene name:  NMU
  • Organism:  Sus scrofa (Pig)
  • Family:  NmU family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006940 regulation of smooth muscle contraction; GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  YFLFRPRN
  • Length:  8
  • Propeptide:  FKVDEEFQGPIVSQNRRYFLFRPRN
  • Signal peptide:  NA
  • Modification:  T8 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Uterus stimulating activity and hypertensive effect ;be synthesized by neuromedin U-25
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NMUR2, NMUR1
  • Target Unid:  F1RQB8, A0A5G2QYE0
  • IC50: NA
  • EC50: 16+/-5nM
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P34964-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004773_AF2.pdbhor004773_ESM.pdb

Physical Information

Mass: 123732 Formula: C54H77N15O11
Absent amino acids: ACDEGHIKMQSTVW Common amino acids: FR
pI: 11.15 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -75 Boman Index: -2574
Half-Life: 2.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: 2 min Aliphatic Index 48.75
Instability Index: 3882.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  3839674
  • Title:  Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord.