General Information

  • ID:  hor004769
  • Uniprot ID:  B3EWI2
  • Protein name:  Allatostatin-A1
  • Gene name:  NA
  • Organism:  Delia radicum (Cabbage root fly) (Anthomyia brassicae)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  Detected in larvae and adults. |In larvae, expressed in the CNS and midgut but not in the ring gland, thoracic perisymapthetic organs (tPSO) or abdominal perisymapthetic organs (aPSO) (at protein level). In adults, expressed in the corpora cardiaca, corpo
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Delia (genus), Anthomyiinae (subfamily), Anthomyiidae (family), Muscoidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  ARPYSFGL
  • Length:  8(1-8)
  • Propeptide:  ARPYSFGL
  • Signal peptide:  NA
  • Modification:  T8 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter or neuromodulator.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 16.5 minutes; /990 seconds ( PubMed ID: 17408666 )

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004769_AF2.pdbhor004769_ESM.pdb

Physical Information

Mass: 103507 Formula: C43H63N11O11
Absent amino acids: CDEHIKMNQTVW Common amino acids: AFGLPRSY
pI: 9.35 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -2.5 Boman Index: -781
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 61.25
Instability Index: 3282.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 212.86

Literature

  • PubMed ID:  20869420
  • Title:  Neuropeptides associated with the central nervous system of the cabbage root fly, Delia radicum (L).
  • PubMed ID:  22848525
  • Title:  Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae).
  • PubMed ID:  17408666
  • Title: