General Information

  • ID:  hor004697
  • Uniprot ID:  Q941C7
  • Protein name:  Tyrosine-sulfated glycopeptide 1
  • Gene name:  PSY1
  • Organism:  Arabidopsis thaliana (Mouse-ear cress)
  • Family:  Sulfated-peptide plant hormone family
  • Source:  Plant
  • Expression:  By wounding. |Expressed in roots, stems, leaves, flowers and shoot apical meristems.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0008083 growth factor activity
  • GO BP:  GO:0007165 signal transduction; GO:0009658 chloroplast organization; GO:0042127 regulation of cell population proliferation
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DYGDPSANPKHDPGVPPS
  • Length:  18(48-65)
  • Propeptide:  MTFVVRLLVCLLLTLTITSSLARNPVSVSGGFENSGFQRSLLMVNVEDYGDPSANPKHDPGVPPSATGQRVVGRG
  • Signal peptide:  MTFVVRLLVCLLLTLTITSSLA
  • Modification:  T2 Sulfotyrosine;T16 4-hydroxyproline;T17 4-hydroxyproline
  • Glycosylation:  T16 O-linked (Ara...) hydroxyproline
  • Mutagenesis:  NA

Activity

  • Function:  Promotes cellular proliferation and expansion. Induces outward H(+) fluxes in roots.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  PSY1R
  • Target Unid:  Q9C7S5
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q941C7-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004697_AF2.pdbhor004697_ESM.pdb

Physical Information

Mass: 215333 Formula: C80H116N22O29
Absent amino acids: CEFILMQRTW Common amino acids: P
pI: 4.31 Basic residues: 2
Polar residues: 6 Hydrophobic residues: 2
Hydrophobicity: -148.89 Boman Index: -4222
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 21.67
Instability Index: 4592.78 Extinction Coefficient cystines: 1490
Absorbance 280nm: 87.65

Literature

  • PubMed ID:  17989228
  • Title:  Tyrosine-sulfated glycopeptide involved in cellular proliferation and expansion in Arabidopsis.
  • PubMed ID:  25267325
  • Title:   Receptor kinase-mediated control of primary active proton pumping at the plasma membrane.