HORDB

ID: hor004669
Uniprot ID: Q9LV97
Protein name: CLAVATA3/ESR (CLE)-related protein 21
Gene name: CLE21
Organism: Arabidopsis thaliana (Mouse-ear cress)
Family: CLV3/ESR signal peptide family
Source: Plant
Expression: [CLE21p]: Mostly expressed in leaves and apex, and, to a lower extent, in seedlings, flowers, stems and siliques.
Disease: NA
Comments: NA
Taxonomy: Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0010078 maintenance of root meristem identity; GO:0010088 phloem development; GO:0030154 cell differentiation; GO:0045168 cell-cell signaling involved in cell fate commitment; GO:0045595 regulation of cell differentiation; GO:0048731 system development
GO CC: GO:0005576 extracellular region; GO:0048046 apoplast

Sequence: SSIQAGRFMTTGRNRNLSVARSLYYKNHHKVVITEMSNFNKVRRRSSRFRRKTDGDEEEEEKRSIPTGPNPLHNK
Length: 75(32-106)
Propeptide: MLILSSRYAMKRDVLIIVIFTVLVLIIISRSSSIQAGRFMTTGRNRNLSVARSLYYKNHHKVVITEMSNFNKVRRRSSRFRRKTDGDEEEEEKRSIPTGPNPLHNK
Signal peptide: MLILSSRYAMKRDVLIIVIFTVLVLIIISRS
Modification: T66 Hydroxyproline;T69 Hydroxyproline
Glycosylation: T16 N-linked (GlcNAc...) asparagine;T69 O-linked (Ara...) hydroxyproline
Mutagenesis: NA

Function: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004669_AF2.pdb

hor004669_ESM.pdb

Mass:	1013791	Formula:	C375H612N128O115S2
Absent amino acids:	CW	Common amino acids:	R
pI:	11.52	Basic residues:	20
Polar residues:	26	Hydrophobic residues:	15
Hydrophobicity:	-133.2	Boman Index:	-29535
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	49.33
Instability Index:	9810	Extinction Coefficient cystines:	2980
Absorbance 280nm:	40.27